Antiphospholipid antibody testing is used to help determine the cause of:

Depending on a person's signs and symptoms and medical history, a healthcare practitioner may order one or more of these tests to help detect the presence of antiphospholipid antibodies and/or to help diagnose antiphospholipid syndrome (APS):

  • Cardiolipin antibodies (IgG, IgM, and sometimes IgA) are frequently ordered since they are the most common antiphospholipid antibodies.
  • Lupus anticoagulant assays (e.g., RVVT, LA-sensitive PTT) if a person has a prolonged PTT test.
  • Beta-2 glycoprotein 1 testing may be ordered along with the other antiphospholipid antibodies to detect their presence and to provide the healthcare practitioner with additional information.

If an antiphospholipid antibody is detected, the same test(s) may be repeated 12 weeks later to determine whether their presence is persistent or temporary.

Testing may also be performed to help diagnose and/or evaluate a person with an autoimmune disorder, which can occur along with disorders like lupus. If a person with an autoimmune disorder tests negative for antiphospholipid antibodies, testing may be repeated to determine if an antibody has developed in the course of the disease.